Ketamine as an Alternative Treatment to ECT in Major Depressive Disorder

Developing more effective and faster acting antidepressant is of outmost clinical importance. Available antidepressant therapies have a delayed therapeutic effect. It typically takes several weeks before symptom relief is evident. Furthermore, antidepressants are relatively ineffective – as many as 30% of patients do not respond to any medication at all.

In this study the investigators evaluate the NMDA-receptor antagonist ketamine as a potentially new antidepressant treatment for severely depressed patients and compare its effectiveness with that of electroconvulsive therapy (ECT).

Topic Depression
Compound Ketamine
Country Sweden
Visit trial
Status Completed
Results Published
Start date 02 January 2015
End date 08 January 2019
Chance of happening 100%
Phase Phase II Phase III
Design Open
Type Interventional
Participants 198
Sex All
Age 18- 85
Therapy No

Trial Details

Developing more effective and faster acting antidepressant is of outmost clinical importance. Available antidepressant therapies have a delayed therapeutic effect. It typically takes several weeks before symptom relief is evident. Furthermore, antidepressants are relatively ineffective - as many as 30% of patients do not respond to any medication at all. In this study the investigators evaluate the NMDA-receptor antagonist ketamine as a potentially new antidepressant treatment for severely depressed patients and compare its effectiveness with that of electroconvulsive therapy (ECT).

NCT Number NCT02659085

Sponsors & Collaborators

Lund University
This company doesn't have a full profile yet, it is linked to a clinical trial.

Measures Used

Montgomery-Asberg Depression Rating Scale
A ten-item diagnostic questionnaire used to measure the severity of depressive symptoms in patients with mood disorders.

Data attribution

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