Endogenous Opioid Modulation by Ketamine

Demonstrate the acute effects of ketamine on endogenous µ-opioid neurotransmission in humans.

Topic Depression

Compound Placebo Ketamine

Country United States of America

Visit trial

Status Withdrawn

Results Published

Start date 08 January 2019

End date 08 January 2019

Chance of happening 0%

Phase Phase III

Design Blinded

Type Interventional

Generation First

Participants 0

Sex All

Age 18- 65

Therapy No

Trial Details

This study will test the hypothesis that the rapidly-acting antidepressant ketamine improves core depressive symptoms by acutely activating the brain's endogenous µ-opioid system.

NCT Number NCT03051945

Sponsors & Collaborators

University of Wisconsin-Madison
The Transdisciplinary Center for Research in Psychoactive Substances (TCRPS) was launched at the University of Wisconsin-Madison in 2021.

Measures Used

Hamilton Depression Rating Scale
The Hamilton Depression Rating Scale (HDRS) is a multiple item questionnaire used to provide an indication of depression, and as a guide to evaluating recovery. The scale consists of 17 items which each item being scoring on a 3 or 5 point scale. The higher the score, the more likely a person is depressed.

Data attribution

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