Effects of Salvinorin A in Healthy Controls

This study evaluates the effects of Salvinorin A (SA). SA is the active ingredient of the plant Salvia divinorum that is known to have been used by Mexican Indians as part of religious rituals. The purpose of this project is to understand what people experience when they consume Salvinorin A.

Topic Healthy Subjects
Compound Placebo Salvia Divinorum
Country United States of America
Visit trial
Status Active, not recruiting
Results Published
Start date 01 January 2009
End date 12 January 2021
Chance of happening 100%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 41
Sex All
Age 18- 45
Therapy No

Trial Details

This study evaluates the effects of Salvinorin A (SA). SA is the active ingredient of the plant Salvia divinorum that is known to have been used by Mexican Indians as part of religious rituals. The purpose of this project is to understand what people experience when they consume Salvinorin A.

NCT Number NCT00700596

Sponsors & Collaborators

Yale University
The Yale Psychedelic Science Group was established in 2016.

National Institute on Drug Abuse
This company doesn't have a full profile yet, it is linked to a clinical trial.

Papers

Dose-related Behavioral, Subjective, Endocrine and Psychophysiological Effects Of the Kappa Opioid Agonist Salvinorin A in Humans
This double-blind, randomized controlled trial (n=10) assessed the behavioural, subjective, cognitive, psychophysiological and endocrine effects of Salvia divinorum (0, 8 and 12 mg) in healthy participants. Salvia produced psychotomimetic effects and perceptual alterations, including dissociative and somaesthetic effects, increased plasma cortisol and prolactin and reduced resting EEG spectral power, but did not produce euphoria, cognitive deficits or changes in vital signs. Overall, Salvia was well tolerated.

Measures Used

States of Consciousness Questionnaire
The States of Consciousness Questionnaire (SOCQ) was developed to assess the occurrence features of the change in consciousness induced by psilocybin and includes the Mystical Experience Questionnaire (MEQ). The SOCQ consists of 100 items, 43 of which are from the MEQ.

Data attribution

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