This trial (n=20) investigates the effects of psilocybin (18.2mg/70kg) on several brain measures and sleep quality. Healthy volunteers aged between 28 and 65 years with no psychiatric history or family history of psychotic disorders will participate.
Psilocybin, administered orally via capsules, will be compared to a placebo to analyze its effects on brain connectivity using functional magnetic resonance imaging (fMRI) and quantitative electroencephalography (qEEG). The study will also assess psychopathological changes associated with psilocybin administration. Secondary objectives include comparing the validity of findings in the human model with an analogous animal model and findings in patients suffering from schizophrenia, with a focus on understanding the role of the serotonergic system in the etiology of schizophrenia.
Trial Details
NCT Number 2012-004579-37
Sponsors & Collaborators
National Institute of Mental HealthThis company doesn't have a full profile yet, it is linked to a clinical trial.
Papers
The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant ActionThis randomized, double-blind, placebo-controlled, within-subjects study (n=17) investigated the effects of psilocybin (18.2mg/70kg) on brain rhythms during sleep and found that it increased the transition period from wakefulness to REM sleep and reduced the duration of the REM period. These results are in line with the effects of other antidepressants and diametrically opposed to biomarkers of depression that include shortened wakefulness to REM transitions and increased REM duration and density.
Psilocybin disrupts sensory and higher order cognitive processing but not pre-attentive cognitive processing—study on P300 and mismatch negativity in healthy volunteers
This double-blind placebo-controlled cross-over study (n=20) found that psilocybin (18.2mg/70kg) disrupted certain auditory-related brain signals (P300, not MMN) which decreased in amplitude in correlation with higher psilocin serum levels (and more intense psychedelic experiences).