Sustained effects of single doses of classical psychedelics in humans

This review (2022) explores the acute effects of classic psychedelics in clinical research with humans and summarizes behavioural, biochemical, neuroimaging and electrophysiological data in order to support the notion that the intriguing effects of psychedelics on the human brain and mind are based on neural plasticity.

Abstract

“The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca). The acute effects of these compounds are well-known as are their ability to increase the emotional state both in healthy people and in those with neuropsychiatric disorders. In particular psilocybin, the psychoactive constituent in “magic mushrooms”, has shown great potential for the treatment of anxiety and depression. A unique and compelling feature of psychedelics is that intake of just a single psychedelic dose is associated with long-lasting effects. This includes effects on personality, e.g., higher openness, and amelioration of depressive symptoms. This review focuses on these stunning effects and summarizes our current knowledge on which behavioural, biochemical, neuroimaging, and electrophysiological data support that the intriguing effects of psychedelics on the human brain and mind are based on neural plasticity. The review also points to so far understudied areas and suggests research questions to be addressed in future studies which potentially can help to understand the intriguing long-term effects after intake of a single (or a few) psychedelic doses.”

Authors: Gitte M. Knudsen

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Sustained effects of single doses of classical psychedelics in humans

https://doi.org/10.1038/s41386-022-01361-x

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Published in
Neuropsychopharmacology
January 1, 1970
citations

Study details

Compounds studied
Psilocybin LSD DMT Mescaline

Topics studied
Neuroscience

Study characteristics
Literature Review

Authors

Authors associated with this publication with profiles on Blossom

Gitte Knudsen
Gitte Moos Knudsen is the Chair Professor at the Neurology and Neurobiology Research Unit, Copenhagen University Hospital, and director of the Center for Experimental Medicine Neuropharmacology (NeuroPharm).

Institutes

Institutes associated with this publication

University of Copenhagen
The Neurobiology Research Unit (NRU) at Copenhagen University Hospital have been carrying clinical and preclinical research with psychedelics since 2017.

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