MDMA for the Treatment of Negative Symptoms in Schizophrenia

This paper (2022) makes the case for using MDMA to treat symptoms of schizophrenia and proposes possible mechanisms of action.


“The profound economic burden of schizophrenia is due, in part, to the negative symptoms of the disease, which can severely limit daily functioning. There is much debate in the field regarding their measurement and classification and there are no FDA-approved treatments for negative symptoms despite an abundance of research. 3,4-Methylenedioxymethamphetamine (MDMA) is a schedule I substance that has emerged as a novel therapeutic given its ability to enhance social interactions, generate empathy, and induce a state of metaplasticity in the brain. This review provides a rationale for the use of MDMA in the treatment of negative symptoms by reviewing the literature on negative symptoms, their treatment, MDMA, and MDMA-assisted therapy. It reviews recent evidence that supports the safe and potentially effective use of MDMA to treat negative symptoms and concludes with considerations regarding safety and possible mechanisms of action.”

Authors: Mitchell D. Arnovitz, Andrew J. Spitzberg, Ashkhan J. Davani, Nehal P. Vadhan, Julie Holland, John M. Kane & Timothy I. Michaels

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MDMA for the Treatment of Negative Symptoms in Schizophrenia

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Published in
Journal of Clinical Medicine
June 7, 2022

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Julie Holland
Julie Holland, M.D., is an American psychopharmacologist, psychiatrist, and author. Next to writing Ecstasy, she has written books about her experience working as an ER doctor in Bellevue Hospital in New York.

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