Long-term Amelioration of OCD Symptoms in a Patient with Chronic Consumption of Psilocybin-containing Mushrooms

This case report (n=1) describes the self-medication outcomes of a patient with treatment-resistant obsessive-compulsive disorder (OCD) who ingested psilocybin-containing mushrooms (2g dried weight; Psilocybe caerulescens) every 2 weeks over a 6 month period. He reported feelings of dissociation without hallucination and the disappearance of OCD symptoms 1 hour after ingestion and was able to perform most of his daily tasks and work without interruptions which meaningfully improved his wellbeing and quality of life for two weeks after each ingestion. The Yale-Brown Obsessive Compulsive Scale confirmed that his obsessive thoughts and compulsions, as well as the rumination, worry and anxiety, and checking behavior, had been significantly reduced over the course of treatment

Abstract

“Introduction: Obsessive Compulsive Disorder (OCD) is a chronic neuropsychiatric condition, characterized by obsessions and compulsions, which is usually disabling for the suffering individual. The first-line treatment is not effective in all patients. There is evidence showing the effectiveness of psilocybin and psilocybincontaining mushrooms in the treatment of OCD symptoms.

Methods/Results: We present the case of a male adult with OCD who showed a clinically meaningful reduction of his OCD symptomatology after the consumption of psilocybin-containing mushrooms.

Discussion: Future research will determine if psilocybin and other psychoactive compounds of psilocybin-containing mushrooms are effective and safe for the treatment of OCD.”

Authors: Agustin Lugo-Radillo & Jorge Luis Cortes-Lopez