Immunological Effects of Ayahuasca in Humans

This meta-analysis (2014) examined double-blind, placebo-controlled clinical trials of acute ayahuasca administration and studies of long-term ayahuasca consumption that investigated its effects on the immune system. They found evidence that it reduces bloodstream levels of CD3 and CD4-type lymphocytes and increases the level of natural killer cells, or large granular lymphocytes, in the acute phase but not in the long term.

Abstract

“Ayahuasca is a botanical hallucinogen traditionally used by indigenous groups of the northwest Amazon. In the last decade, the use of ayahuasca has spread from Brazil, Colombia, Ecuador, and Peru to the U.S., Europe, Asia, and Africa. Despite acute and long-term evidence of good tolerability and safety for ayahuasca administered in the laboratory or ritually consumed in religious contexts, little is known about the immunological impact of ayahuasca on humans. Since ayahuasca is used by an increasing number of consumers, and considering its therapeutic potential, more information is needed regarding ayahuasca potential risks. This article presents a brief overview of the available data regarding the immunological impact of ayahuasca in humans.”

Author: Rafael G. dos Santos

Summary of Immunological Effects of Ayahuasca in Humans

Introduction

Ayahuasca is a botanical preparation with hallucinogenic effects used by several northwestern Amazonian indigenous groups for initiatory rites, war, hunting, and healing. It is also used therapeutically by Mestizo populations in Amazonian countries.

Ayahuasca is rich in the -carboline alkaloids harmine, tetrahydroharmine (THH), and harmaline, and the hallucinogenic tryptamine dimethyltryptamine (DMT). These compounds act as reversible inhibitors of the enzyme monoamine oxidase-A, and DMT can reach the central nervous system via the 5-HT2A receptor.

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Study details

Compounds studied
Ayahuasca

Topics studied
Immunity

Study characteristics
Meta-Analysis Literature Review