Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women

This review (2022) focuses on using ketamine to treat mood disorders in women. The cause of depression in women, the preclinical research on the neurobiological effects of ketamine and how these effects interact with ovarian hormones are some of the topics discussed.

Abstract

“Ketamine has been shown to acutely and rapidly ameliorate depression symptoms and suicidality. Given that women suffer from major depression at twice the rate of men, it is important to understand how ketamine works in the female brain. This review explores three themes. First, it examines our current understanding of the aetiology of depression in women. Second, it examines preclinical research on ketamine’s antidepressant effects at a neurobiological level as well as how ovarian hormones present a unique challenge in interpreting these findings. Lastly, the neuroinflammatory hypothesis of depression is highlighted to help better understand how ovarian hormones might interact with ketamine in the female brain.”

Authors: Collin Gagne, Alexandre Piot & Wayne G. Brake

Study details

Compounds studied
Ketamine

Topics studied
Postpartum Depression Treatment-Resistant Depression Depression

Study characteristics
Literature Review

Participants
0 Humans

PDF of Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women