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Our vision is that psychedelics can be used worldwide to better the lives of as many as 450 million people who suffer from mental health problems. Our information hopes to make that vision come to life just a little faster.
Here will be a narrative, readable, summary of the research.
In our literature study we came across the following studies of note. Browse the meta, review, commentary articles for an overview. Check out the individual studies for specific experiments and observations.
A Systematic Review of the MDMA Model to Address Social Impairment in Autism
2021 | Albrecht, M., Chaliha, D., Lam, V., Mamo, J. C., Takechi, R., Vaccarezza, M.
This systematic review (2021) examines whether MDMA can treat social impairments of autism, and draws supporting evidence from animal models which indicate MDMA-induced prosocial behaviors.
The use of psychedelic agents with autistic schizophrenic children
1971 | Aldrich, R. W., Mogar, R. E.
This review (1971) of 7 studies looked at the effect of psychedelics in autistic children (n=91). Psychedelics led to improved speech and mood, better emotional responsiveness, and decreased compulsive behaviour.
A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy
2020 | Bathje, G. J., Chwyl, C., Davis, A. K., Lancelotta, R., Luoma, J. B.
This meta-analysis of nine placebo-controlled trials (n=211) showed a very large effect size (g=1.21) of treatment on four mental health conditions (PTSD, end-of-life anxiety, depression, social anxiety among autistic adults).
Autistic Schizophrenic Children: An Experiment in the Use of D-Lysergic Acid Diethyladmide (LSD-25)
1977| Freedman, A. M.
This early study (1962; n=12) with LSD (50-200µg) on children with autism (ASD) and schizophrenia, of which 7 were mute, showed that LSD elicited large psychological changes in this population, but no change in muteness. Procedures for consent were different/non-existent at that time.
Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study
2018| Danforth, A. L., Emerson, A., Feduccia, A. A., Grob, C. S., Jerome, L., Struble, C., Walker, N., Yazar-Klosinski, B.
This double-blind, placebo-controlled, randomized pilot study (n=12) found a significant reduction in social anxiety (d=1.4) after MDMA-assisted psychotherapy (75-125mg, 2 sessions). The effects persisted even 6-months later (d=1.1).
This section compares the research with psychedelics to other therapies, medicines, or treatments.
This section highlights the various measures used and their use in research.
Who are the top researches in this area, the ones who have done the groundbreaking research.
What do we not know at this time? Where are the gaps in our knowledge and are we closing it?
The companies that are actively engaged in researching this topic or (planning to) provide therapy focussed on this topic.
This section highlights everything done outside of academia, from popular press to books and non academic research.